• Volume 1, Issue 3
    September 2023

ISSUE INFORMATION

Open Access

Issue Information

  • First Published: 27 July 2023

REVIEW ARTICLE

Open Access

Understanding the brain with attention: A survey of transformers in brain sciences

  • First Published: 12 October 2023
Description unavailable

This survey provides a comprehensive review of the development and application for Transformers in brain sciences. It covers eight widely concerned brain science scenarios to provide vital details and discussions for the latest Transformer researches. By exploring the current challenges and potential research directions, it would be expected to provide a convenient reference for researchers in related fields.

REVIEW ARTICLE

Open Access

Understanding the role of inflammation in sensorineural hearing loss: Current goals and future prospects

  • First Published: 12 October 2023
Description unavailable

This paper describes the role of inflammation in sensorineural hearing loss (SNHL). Inflammation affects SNHL primarily via cochlear immunity, microcirculation, vasospasm, and glutamate metabolism, often accompanied by immune cell infiltration, altered blood flow, ischemic damage, and synaptic injury. A comprehensive anti-inflammatory approach is undesirable, and studying inflammation-related mechanisms will aid the search for potential targets in SNHL.

RESEARCH ARTICLE

Open Access

Edge-centric functional network reveals new spatiotemporal biomarkers of early mild cognitive impairment

  • First Published: 12 October 2023
Description unavailable

In contrast to existing studies that focus on the correlations between brain regions, our study is based on the high-order edge network and innovated to explore the correlation between brain region pairs from the perspective of space and time, search for new biomarkers, and explore the pathogenesis of early mild cognitive impairment, which is conducive to delaying its development to Alzheimer's disease and promoting medical developments.

REVIEW ARTICLE

Open Access

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

  • First Published: 10 October 2023
Description unavailable

This review provides an extensive overview of the recent advancements in reactive oxygen species (ROS)-targeted biomaterials tailored for spinal cord injury (SCI) treatment, emphasizing their ability to effectively clean excessive ROS, modulate inflammation, and reduce secondary injuries. The review also showcases their potential for future translational research involving SCI clinical therapies, which will enable the ongoing enhancement and optimization of these biomaterials to benefit individuals with SCIs.

PERSPECTIVE

Open Access

Understanding the heterogeneous immune repertoire of brain metastases for designing next-gen therapeutics

  • First Published: 01 October 2023
Description unavailable

Advanced cancer patients often develop brain metastases, but their molecular and immunological features remain poorly understood due to challenges in biopsy. This perspective highlights recent advances in immune landscape profiling of brain metastases, with an emphasis on tumor-reactive T cells, and summarizes innovative technologies for tracking tumor dynamics and designing targeted therapies.

REVIEW ARTICLE

Open Access

The mechanism of bone healing after traumatic brain injury

  • First Published: 28 September 2023
Description unavailable

This review discusses the fundamental mechanisms underpinning the accelerated bone regeneration seen in individuals with traumatic brain injuries (TBIs), emphasizing the importance of the nuanced interplay between TBIs and the bone remodeling process.

PERSPECTIVE

Open Access

ChatGPT: The cognitive effects on learning and memory

  • First Published: 20 September 2023
Description unavailable

The integration of ChatGPT into the domains of learning and memory holds the potential to transform the entire field of education. This article explores the potential positive and negative effects of increased engagement with artificial intelligence, offering strategies for optimizing its benefits while mitigating its drawbacks, and highlights areas that can benefit from further research. In this way, it seeks to ensure that ChatGPT operates as an adjunctive educational tool that complements human cognitive processes without damaging them.

METHODS ARTICLE

Open Access

Prediction of the hand function part of the Fugl-Meyer scale after stroke using an automatic quantitative assessment system

  • First Published: 22 August 2023
Description unavailable

This study aims to quantitatively assess the motor function of the hand in stroke patients with a self-developed system named the Hand Automatic Quantitative Assessment System (HAQAS) using state-of-the-art machine learning algorithms. There were high correlations between features automatically collected by the HAQAS and Fugl-Meyer scales in all the sub-items. Our proposed automatic FMA system is easy and transparent to use in clinical settings and would greatly reduce the workload of physical therapists and clinicians.

RESEARCH ARTICLE

Open Access

Target localization intervention and prognosis evaluation for an individual with mild cognitive impairment

  • First Published: 22 August 2023
Description unavailable

A single brain region state dynamics model was developed to simulate blood oxygen level-dependent signals of a patient with early mild cognitive impairment. Multiple complex network centralities were comprehensively considered to locate the intervention targets, and a multi-brain collaborative control scheme was designed and verified at the brain region and subnetwork levels.

REVIEW ARTICLE

Open Access

Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

  • First Published: 28 July 2023
Description unavailable

The present review details how nanomedicines can treat AD by overcoming the abnormal aggregation of Aβ and Tau, reducing neuronal apoptosis, alleviating neuroinflammation and promoting neuronal regeneration.